Living Organisms
Sigma Aldrich Fine Chemicals Biosciences Escherichia coli Strain B10G
Escherichia coli is a non-pathogenic facultative anaerobic flora present in the intestine of human. It belongs to the genus Escherichia which consists of motile gram-negative bacilli.
Cayman Chemical FrovatrIptnsuccInate hydra 5mg
An agonist of 5-HT1B and 5-HT1D receptors (Kis = 2.51 and 3.98 nM, respectively); selective for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2C, 5-HT3, and 5-HT7 receptors, as well as dopamine D1, D2, and D3, histamine H1, and α1-adrenergic receptors (Kis = >50 nM); induces contractions in human basilar arteries isolated post-mortem, coronary arteries from transplant recipient hearts, and coronary arteries from donor hearts unsuitable for transplantation (EC50s = 13.8, 41.69, and 15.49 nM, respectively); increases carotid vascular resistance in closed-chest and open-chest anesthetized dogs (ED50s = 6 and 1 nmol/kg, i.v., respectively)
Enterprise Technology Solutions Maxell Bass 13 Headphone with
Bass 13 Headphone with Mic 4 ft Cord Black
Cayman Chemical PemetrexedodIM salt hydra 10mg
An antifolate with anticancer activity; an inhibitor of thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively); has increased potency for thymidylate kinase when polyglutaminated (Ki = 1.3 nM); an inhibitor of glycinamide ribonucleotide formyltransferase (Kis = 9,300 and 65 nM for the non-glutaminated and polyglutaminated enzyme) and aminoimidazole carboxamide ribonucleotide formyltransferase (Kis = 3,600 and 265 nM for the non-glutaminated and polyglutaminated, respectively); inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively); reduces tumor growth in A549, H1299, and PC-9 NSCLC mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase
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Grainger Garden Hose Kit PVC
The Coxreels Garden Hose Kit is a 50 foot long, 5/8 inch diameter, heavy duty rubber garden hose with brass fittings. It includes a hose reel cart with 10 inch pneumatic tires and a handle for easy portability around the yard. The reel can hold up to 150 feet of 5/8 inch hose and has a powder coated steel frame. This garden hose kit provides an easy way to neatly store, move and use your garden hose.
Cayman Chemical BIX01294hydrochLRIde hydra 1mg
A selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 μM); less effectively inhibits G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known histone methyltransferases
Cayman Chemical PemetrexedodIM salt hydra 50mg
An antifolate with anticancer activity; an inhibitor of thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively); has increased potency for thymidylate kinase when polyglutaminated (Ki = 1.3 nM); an inhibitor of glycinamide ribonucleotide formyltransferase (Kis = 9,300 and 65 nM for the non-glutaminated and polyglutaminated enzyme) and aminoimidazole carboxamide ribonucleotide formyltransferase (Kis = 3,600 and 265 nM for the non-glutaminated and polyglutaminated, respectively); inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively); reduces tumor growth in A549, H1299, and PC-9 NSCLC mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase
Cayman Chemical LTyrosInsodIum salt hydra 100g
A conditionally essential amino acid; a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones; plasma, skeletal muscle, and erythrocyte levels are decreased in patients with chronic kidney disease
Cayman Chemical Harmalol hydrochloride hydra
A β-carboline alkaloid and an active metabolite of harmaline; an inhibitor of DYRK1A (IC50 = 0.63 µM); an inhibitor of MAO-A (IC50 = 0.66 µM); selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM; inhibits proliferation of H4 human glioblastoma cells (IC50s = 23.7 µM); reduces TCDD-induced increases in CYP1A1 levels in HepG2 cells and prevents TCDD-induced activation of AhR in guinea pig hepatic cytosolic extracts; reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and ROS production in PC12 cells at 25 µM
Cayman Chemical MetIxenhydrochLRIde hydra 25mg
A muscarinic acetylcholine receptor antagonist (Ki = 15 nM for the rat receptor); inhibits bovine AChE by 43% at 10 µM and BChE (IC50 = 1.6 µM for the horse enzyme) in cell-free assays; reduces the proliferation of P388 and P388/ADR leukemia cells (EC50s = 10 and 12 µM, respectively); induces apoptosis in BT474 and MDA-MB-231 cancer cells at 15 µM and induces autophagy in the same cells at 10 µM; decreases tumor weight and volume and improves survival in an MDA-MB-231 breast cancer mouse xenograft model at 1 mg/kg three times per week